STUDIES ON INTERFERON INDUCTION BY NEWCASTLE DISEASE VIRUS (NDV) .I. INTERFERON INDUCTION BY NDV GROWN IN PRIMARY CHICK EMBRYONIC CELLS

Seed stock of Newcastle disease virus (NDV) prepared by infecting primary chick embryo (PCE) cells (CE-NDV) induced interferon production in PCE cells. Unlike the case of egg-grown NDV (EG-NDV), UV irradiation of CE-NDV resulted in a linear decrease of interferon inducing potency. The interferon induction by CE-NDV was not a strain-specific characteristic, seemed to be associated with viral growth, and was interfered by an excess dose of EG-NDV in its very early period of infection. Little has been elucidated about the mechanism which governs the alteration between EG- and CE-NDV type of interferon stimulation. © 1969 Springer-Verlag.