11-OXO-11 H-PYRIDO[2,1-B]QUINAZOLINE-8-CARBOXYLIC ACID, AN ORALLY ACTIVE ANTIALLERGY AGENT

被引：38

作者：

SCHWENDER, CF ^{[1
]}

SUNDAY, BR ^{[1
]}

HERZIG, DJ ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,DIV PHARMACEUT RES,DEPT PHARMACOL,ANN ARBOR,MI 48106

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 01期

关键词：

D O I：

10.1021/jm00187a026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 11-oxo-11H-pyrido|2, 1-b)quina2olinecarboxylic acids and related analogues has been synthesized and evaluated as potential antiallergy agents. In the rat PCA test, 11-oxo-11H-pyrido(2, 1-b]quinazoline-8-carboxvlic acid is orally active and more potent than cromolyn sodium or doxantrazole intravenously. © 1979, American Chemical Society. All rights reserved.

引用

页码：114 / 116

页数：3

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