EFFECT OF PHYSOSTIGMINE AND TETRABENAZINE ON SPINAL MOTOR CONTROL AND ITS INHIBITION BY DRUGS WHICH INFLUENCE RESERPINE RIGIDITY

被引：14

作者：

JURNA, I

THERES, C

BACHMANN, T

机构：

[1] Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg (Saar)

来源：

NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE | 1969年 / 263卷 / 03期

关键词：

Antiparkinson Drugs; Cholinolytic Agents; Monoaminergic Agents; Phenytoin; Physostigmine; Spinal Motor Activity; Tetrabenazine;

D O I：

10.1007/BF00538776

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of monoaminergic (DOPA, metamphetamine, propylhexedrine) and cholinolytic agents (atropine, biperiden, caramiphen, trihexyphenidyl) on spinal motor control disturbed by physostigmine and tetrabenazine was studied in the rat. In addition the anticonvulsant agent phenytoin was included in the investigation. Physostigmine and tetrabenazine produced rigidity, increased α reflex discharge, shortened the latency of α reflex discharge and decreased γ reflex discharge. Rigidity as well as the action of physostigmine and tetrabenazine on α motor activity were inhibited by the drugs. The results are in accordance with the hypothesis that parkinsonlike rigidity in the rat results from hyperactivity of the α motor system, which is due to an imbalance between monoaminergic and cholinergic mechanisms in the brain. © 1969 Springer-Verlag.

引用

页码：427 / &

共 12 条

[1] RECIPROCAL EFFECTS ON ALPHA- AND GAMMA-MOTONEURONES OF DRUGS INFLUENCING MONOAMINERGIC AND CHOLINERGIC TRANSMISSION [J].