TRANSITION-STATE STABILIZATION AND MOLECULAR RECOGNITION - ACCELERATION OF PHOSPHORYL-TRANSFER REACTIONS BY AN ARTIFICIAL RECEPTOR

被引:62
作者
TECILLA, P [1 ]
CHANG, SK [1 ]
HAMILTON, AD [1 ]
机构
[1] UNIV PITTSBURGH, DEPT CHEM, PITTSBURGH, PA 15260 USA
关键词
D O I
10.1021/ja00182a017
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with P-31 NMR methods show that the receptor causes up to a 10-fold accleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.
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页码:9586 / 9590
页数:5
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