ATTENUATION OF SOME SIGNS OF OPIOID WITHDRAWAL BY INHIBITORS OF NITRIC-OXIDE SYNTHASE

被引:88
作者
KIMES, AS
VAUPEL, DB
LONDON, ED
机构
[1] JOHNS HOPKINS MED INST,DEPT RADIOL,BALTIMORE,MD 21205
[2] UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201
关键词
NITRIC OXIDE SYNTHASE INHIBITOR; MORPHINE; DEPENDENCE; WITHDRAWAL; L-N-G-NITROARGININE; RATS; OPIOID WITHDRAWAL;
D O I
10.1007/BF02244904
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Effects of nitric oxide synthase (NOS) inhibitors (L-N-G-nitroarginine, L-N-G-nitroarginine methyl ester) on precipitated opioid withdrawal were studied in morphine-dependent rats given naloxone, in order to assess the involvement of nitric oxide (NO) in opioid dependence. L-N-G-Nitroarginine (7.5mg/kg, IP, 1 h before naloxone or b.i.d. on days 4-7 of an 8-day morphine treatment) reduced wet dog shakes and weight loss; when given by osmotic pumps (15 mg/kg per day), the drug reduced wet dog shakes but not weight loss. L-N-G-Nitroarginine methyl ester (60 mg/kg, 1 h before naloxone) also reduced wet dog shakes and weight loss. The results indicate that NOS inhibitors warrant further study as potential treatments of the opioid withdrawal syndrome.
引用
收藏
页码:521 / 524
页数:4
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