ANTINEOPLASTIC AND ANTIVIRAL ACTIVITIES OF PODOPHYLLOTOXIN RELATED LIGNANS

被引：54

作者：

GORDALIZA, M ^{[1
]}

CASTRO, MA ^{[1
]}

GARCIAGRAVALOS, MD ^{[1
]}

RUIZ, P ^{[1
]}

DELCORRAL, JMM ^{[1
]}

SANFELICIANO, A ^{[1
]}

机构：

[1] PHARMAMAR SA, E-28070 MADRID, SPAIN

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 03期

关键词：

D O I：

10.1002/ardp.19943270309

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while antiviral assays were performed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both groups of assays at concentrations below 1 mu M; deoxypodophyllotoxin (1) being the most potent compound in all cases.

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页码：175 / 179

页数：5

相关论文

共 21 条

[1]

Ayres D.C, 1990, LIGNANS CHEM BBIOLOG

[2] LIGNANS .2. REDUCTION OF LACTONES OF PODOPHYLLOTOXIN GROUP WITH LITHIUM ALUMINIUM HYDRIDE [J].

AYRES, DC ;

PAUWELS, PJS .

JOURNAL OF THE CHEMICAL SOCIETY, 1962, (DEC) :5025-&

[3] PROMOTION OF FLUORESCENCE UPON BINDING OF COLCHICINE TO TUBULIN [J].

BHATTACH.B ;

WOLFF, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (07) :2627-2631

[4] CONFORMATIONAL-ANALYSIS OF PODOPHYLLOTOXIN AND ITS CONGENERS - STRUCTURE-ACTIVITY RELATIONSHIP IN MICROTUBULE ASSEMBLY [J].

BREWER, CF ;

LOIKE, JD ;

HORWITZ, SB ;

STERNLICHT, H ;

GENSLER, WJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (03) :215-221

[5] THERMAL CHEMISTRY OF PODOPHYLLOTOXIN IN ETHANOL AND A COMPARISON OF THE CYTOSTATIC ACTIVITY OF THE THERMOLYSIS PRODUCTS [J].

BUCHARDT, O ;

JENSEN, RB ;

HANSEN, HF ;

NIELSEN, PE ;

ANDERSEN, D ;

CHINOIN, I .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (11) :1076-1080

[6] COMPONENTS OF PODOPHYLLIN .10. RELATION OF ALPHA-PELTATIN TO BETA-PELTATIN [J].

HARTWELL, JL ;

SCHRECKER, AW ;

GREENBERG, GY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (24) :6285-6287

[7] SYNTHESIS AND ANTITUMOR-ACTIVITY OF STRUCTURAL ANALOGS OF THE EPIPODOPHYLLOTOXINS [J].

KLEIN, LL ;

YEUNG, CM ;

CHU, DT ;

MCDONALD, EJ ;

CLEMENT, JJ ;

PLATTNER, JJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) :984-992

[8] RESPONSE OF SOLITARY PSORIATIC PLAQUES TO EXPERIMENTAL APPLICATION OF PODOPHYLLOTOXIN [J].

LASSUS, A ;

ROSEN, B .

DERMATOLOGICA, 1986, 172 (06) :319-322

[9]

LOIKE JD, 1978, CANCER RES, V38, P2688

[10] BIOLOGICAL-ACTIVITIES OF LIGNANS [J].

MACRAE, WD ;

TOWERS, GHN .

PHYTOCHEMISTRY, 1984, 23 (06) :1207-1220