ACETYLCHOLINE-RELEASE IN THE HIPPOCAMPUS - EFFECTS OF CHOLINERGIC AND GABAERGIC COMPOUNDS IN THE MEDIAL SEPTAL AREA

被引：55

作者：

GORMAN, LK ^{[1
]}

PANG, K ^{[1
]}

FRICK, KM ^{[1
]}

GIVENS, B ^{[1
]}

OLTON, DS ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,DEPT PSYCHOL,BALTIMORE,MD 21218

来源：

NEUROSCIENCE LETTERS | 1994年 / 166卷 / 02期

关键词：

ACETYLCHOLINE; MICRODIALYSIS; INTRASEPTAL INFUSION; HIPPOCAMPUS; GABA;

D O I：

10.1016/0304-3940(94)90485-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed using in vivo microdialysis and HPLC-EC. Oxotremorine and scopolamine produced a dose-dependent decrease in hippocampal ACh release. Muscimol decreased hippocampal ACh release at both high and low doses, although not in a dose-dependent manner. The effects of scopolamine and muscimol are consistent with a role of ACh in mnemonic processing.

引用

页码：199 / 202

页数：4

共 28 条

[1] DISTRIBUTION OF GLUTAMATE-DECARBOXYLASE-IMMUNOREACTIVE NEURONS AND SYNAPSES IN THE RAT AND MONKEY HIPPOCAMPUS - LIGHT AND ELECTRON-MICROSCOPY [J].