CHANGES IN TISSUE CYCLIC-AMP CONCENTRATIONS FOLLOWING AN INTRAVENOUS LETHAL DOSE OF CHOLERA ENTERO-TOXIN IN RABBITS

被引:4
作者
LIU, CT
GALLOWAY, EJ
机构
关键词
D O I
10.1016/0041-0101(81)90107-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A generalized increase in tissue cAMP concentrations after an i.v. injection of cholera enterotoxin may play a role in the development of biochemical and pathological changes leading to death. Dutch rabbits were injected i.v. with highly purified cholera enterotoxin at a dose of 100 or 200 .mu.g/kg. When death appeared imminent (20-30 h after inoculation), rabbits were anesthetized; plasma, urine and 13 different tissue samples were obtained for cAMP determinations. Enterotoxin (200 .mu.g/kg) produced significant increases in cAMP concentrations in lung, spinal cord, skeletal muscle, renal cortex, renal medulla and liver, whereas a lower dose (100 .mu.g/kg) had no effect on cAMP levels in any tissue. The elevation of cAMP values in selected tissues suggests differences in tissue sensitivity to cholera enterotoxin; the data fail to support in toto the proposed hypothesis.
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页码:701 / 704
页数:4
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