BIOAVAILABILITY OF BISMUTH FROM BI-205-LABELED PHARMACEUTICAL ORAL BI-PREPARATIONS IN RATS

被引：19

作者：

DRESOW, B ^{[1
]}

NIELSEN, P ^{[1
]}

FISCHER, R ^{[1
]}

WENDEL, J ^{[1
]}

GABBE, EE ^{[1
]}

HEINRICH, HC ^{[1
]}

机构：

[1] ZYKLOTRON KERNFORSCHUNGSZENTRUM KARLSRUHE,INST KERNPHYS,W-7500 KARLSRUHE,GERMANY

来源：

ARCHIVES OF TOXICOLOGY | 1991年 / 65卷 / 08期

关键词：

BISMUTH THERAPY; HELICOBACTER-PYLORI; BIOLOGICAL HALF-LIFE; TISSUE DISTRIBUTION;

D O I：

10.1007/BF02098030

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The bioavailability of Bi-205 from various Bi-205-labelled pharmaceutical oral bismuth preparations was studied in rats. The intestinal absorption, calculated from Bi-205 whole body retention and accumulated Bi-205 urinary excretion, was small in general, but significantly higher (0.26-0.33% of dose) from oral bismuth citrates (basic bismuth citrate, colloidal bismuth subcitrate) as compared to basic bismuth nitrate, salicylate, gallate, and bismuth aluminate (0.04-0.11% of dose). After oral administration, the retained bismuth was mainly accumulated in the kidney, followed by bone, red blood cells and the lung. The whole body retention, faecal and urinary excretions of Bi-205 were described by a three-compartment model. Biological Bi-205 half-lives of 10, 36 and 295 h were derived in rats.

引用

页码：646 / 650

页数：5

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