IMMUNIZATION OF RABBITS WITH ENTEROTOXIGENIC ESCHERICHIA-COLI COLONIZATION FACTOR ANTIGEN (CFA/I) ENCAPSULATED IN BIODEGRADABLE MICROSPHERES OF POLY (LACTIDE-CO-GLYCOLIDE)

被引：68

作者：

EDELMAN, R ^{[1
]}

RUSSELL, RG ^{[1
]}

LOSONSKY, G ^{[1
]}

TALL, BD ^{[1
]}

TACKET, CO ^{[1
]}

LEVINE, MM ^{[1
]}

LEWIS, DH ^{[1
]}

机构：

[1] MEDISORB TECHNOL INT LP, CINCINNATI, OH 45242 USA

来源：

VACCINE | 1993年 / 11卷 / 02期

关键词：

ENTEROTOXIGENIC ESCHERICHIA-COLI; ORAL VACCINE; FIMBRIAL ADHESIN; MICROSPHERES; BIODEGRADABLE POLYMER;

D O I：

10.1016/0264-410X(93)90012-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have searched for an effective oral delivery system for a purified enterotoxigenic Escherichia coli (ETEC) fimbrial adhesin, CFA/I, which elicits anti-colonization immunity. Purified CFA/I antigen encapsulated in biodegradable polymer microspheres of poly (DL-lactide-co-glycolide) (PLG) induced a vigorous, systemic CFA/I IgG antibody response in rabbits immunized once via intragastric tube; oral, unencapsulated CFA/I induced little or no circulating antibody. CFA/I-specific, S-IgA coproantibody was detected in one of three rabbits fed with the CFA/I-PLG microsphere vaccine. We conclude that PLG microspheres protected CFA/I from degradation in the stomach and effectively delivered the antigen for processing by the host's immune system.

引用

页码：155 / 158

页数：4

共 18 条

[1] POLY(DL-LACTIDE-CO-GLYCOLIDE) NORETHISTERONE MICROCAPSULES - AN INJECTABLE BIODEGRADABLE CONTRACEPTIVE
BECK, LR
POPE, VZ
FLOWERS, CE
COWSAR, DR
TICE, TR
LEWIS, DH
DUNN, RL
MOORE, AB
GILLEY, RM
[J]. BIOLOGY OF REPRODUCTION, 1983, 28 (01) : 186 - 195
[2] LONGITUDINAL-STUDIES OF INFECTIOUS-DISEASES AND PHYSICAL GROWTH OF CHILDREN IN RURAL BANGLADESH .2. INCIDENCE OF DIARRHEA AND ASSOCIATION WITH KNOWN PATHOGENS
BLACK, RE
BROWN, KH
BECKER, S
ALIM, ARMA
HUQ, I
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1982, 115 (03) : 315 - 324
[3] BOEDEKER EC, 1989, IMMUNOLOGY IMMUNOPAT, P435
[4] ELDRIDGE JH, 1989, CURR TOP MICROBIOL, V146, P59
[5] PURIFICATION AND ANALYSIS OF COLONIZATION FACTOR ANTIGEN-I, COLI SURFACE ANTIGEN-1, AND COLI SURFACE ANTIGEN-3 FIMBRIAE FROM ENTERO-TOXIGENIC ESCHERICHIA-COLI
HALL, RH
MANEVAL, DR
COLLINS, JH
THEIBERT, JL
LEVINE, MM
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (11) : 6372 - 6374
[6] DIARRHEAL DISEASE DURING OPERATION-DESERT-SHIELD
HYAMS, KC
BOURGEOIS, AL
MERRELL, BR
ROZMAJZL, P
ESCAMILLA, J
THORNTON, SA
WASSERMAN, GM
BURKE, A
ECHEVERRIA, P
GREEN, KY
KAPIKIAN, AZ
WOODY, JN
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (20) : 1423 - 1428
[7] PROGRESS TOWARDS A VACCINE AGAINST ENTERO-TOXIGENIC ESCHERICHIA-COLI
KAPER, JB
LEVINE, MM
[J]. VACCINE, 1988, 6 (02) : 197 - 199
[8] Levine M, 1986, PROTEIN CARBOHYDRATE, P143
[9] COLI SURFACE ANTIGEN-1 AND ANTIGEN-3 OF COLONIZATION FACTOR ANTIGEN-II-POSITIVE ENTERO-TOXIGENIC ESCHERICHIA-COLI - MORPHOLOGY, PURIFICATION, AND IMMUNE-RESPONSES IN HUMANS
LEVINE, MM
RISTAINO, P
MARLEY, G
SMYTH, C
KNUTTON, S
BOEDEKER, E
BLACK, R
YOUNG, C
CLEMENTS, ML
CHENEY, C
PATNAIK, R
[J]. INFECTION AND IMMUNITY, 1984, 44 (02) : 409 - 420
[10] SYSTEMIC AND MUCOSAL IMMUNE-RESPONSES TO RHESUS ROTAVIRUS VACCINE MMU-18006
LOSONSKY, GA
RENNELS, MB
LIM, Y
KRALL, G
KAPIKIAN, AZ
LEVINE, MM
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1988, 7 (06) : 388 - 393

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