T-CELLS, BUT NOT B-CELLS, ARE REQUIRED FOR BOWEL INFLAMMATION IN INTERLEUKIN 2-DEFICIENT MICE

被引：124

作者：

MA, A

DATTA, M

MARGOSIAN, E

CHEN, JZ

HORAK, I

机构：

[1] CHILDRENS HOSP, BOSTON, MA 02115 USA

[2] BETH ISRAEL HOSP, BOSTON, MA 02115 USA

[3] BRIGHAM & WOMENS HOSP, BOSTON, MA 02115 USA

[4] UNIV WURZBURG, INST VIROL & IMMUNOBIOL, D-97078 WURZBURG, GERMANY

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1995年 / 182卷 / 05期

关键词：

D O I：

10.1084/jem.182.5.1567

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-2 (IL-2)-deficient (IL-2(-/-)) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2(-/-) mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2(-/-), lacking B and T cells) and JH-deficient mice (JH(-/-), lacking B cells). IL-2(-/-), RAG-2(-/-) double-mutant mice are disease free, while IL-2(-/-), JH(-/-) double-mutant mice succumb to bowel disease at the same rate as IL-2(-/-) littermates. IL-2(-/-), JH(-/-) mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2(-/-) mice requires mature T cells, not B cells, while anemia is dependent on B cells.

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收藏

页码：1567 / 1572

页数：6

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