A NEW ALPHA-SELECTIVE SYNTHETIC EQUIVALENT FOR THE CROTYL ANION IN ADDITIONS TO IMINES

被引:19
作者
BETZ, J [1 ]
HEUSCHMANN, M [1 ]
机构
[1] UNIV MUNICH,INST ORGAN CHEM,D-80333 MUNICH,GERMANY
关键词
D O I
10.1016/0040-4039(95)00670-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two equivalents of vinylmagnesium bromide add to imines 1 in the presence of cerium trichloride to form homoallylic amines 3 as 2:1-adducts, Z-diastereomers being preferred by a margin of 88:12 to 71:29. Suitable chiral imines 1g-i are transformed to l-products l-3g-i with high diastereoselectivity.
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页码:4043 / 4046
页数:4
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