LSD - AUTORADIOGRAPHIC STUDY ON PLACENTAL TRANSFER AND TISSUE DISTRIBUTION IN MICE

被引：31

作者：

IDANPAAN.JE

SCHOOLAR, JC

机构：

[1] Texas Research Institute, Houston, TX 77025

[2] Department of Pharmacology, University of Helsinki, Helsinki

来源：

SCIENCE | 1969年 / 164卷 / 3885期

关键词：

D O I：

10.1126/science.164.3885.1295

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

14C-lysergic acid diethylamide administered intravenously passed in a few minutes from the blood into the tissues. In addition to the brain, the adrenals, hypophysis, kidneys, liver, and lungs showed the highest uptake, much higher than the blood concentration. Excretion into the bile started immediately; this was the most important elimination route. In the early stage of pregnancy, 2.5 percent (and in the late stage, 0.5 percent) of the radioactive dose passed the placental barrier into the fetus in 5 minutes. Over 70 percent of this fetal radioactivity was unchanged 14C-lysergic acid diethylamide.

引用

页码：1295 / &

共 25 条

[1] LSD - INJECTION EARLY IN PREGNANCY PRODUCES ABNORMALITIES IN OFFSPRING OF RATS [J].