ISOLATION OF THE ANTIPHLOGISTIC PRINCIPLE FROM EPILOBIUM-ANGUSTIFOLIUM

被引：44

作者：

HIERMANN, A ^{[1
]}

REIDLINGER, M ^{[1
]}

JUAN, H ^{[1
]}

SAMETZ, W ^{[1
]}

机构：

[1] GRAZ UNIV,INST EXPTL & KLIN PHARMAKOL,A-8010 GRAZ,AUSTRIA

来源：

PLANTA MEDICA | 1991年 / 57卷 / 04期

关键词：

EPILOBIUM-ANGUSTIFOLIUM; ANTIPHLOGISTIC PRINCIPLE; ANTIINFLAMMATORY ACTION; INHIBITION OF PROSTAGLANDIN BIOSYNTHESIS; MYRICETIN; 3-O-BETA-D-GLUCURONIDE;

D O I：

10.1055/s-2006-960117

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the leaves of Epilobium angustifolium L. (Onagraceae) an antiphlogistic principle was isolated and identified as myricetin 3-O-beta-D-glucuronide. This novel flavonoid exhibited a very strong anti-inflammatory effect on carrageenan-induced edema in the rat hind paw (more than ten times more effective than indomethacin) and an inhibitory effect on prostaglandin biosynthesis (as effective as indomethacin).

引用

页码：357 / 360

页数：4

共 17 条

[1] FLAVONOIDS AND RELATED-COMPOUNDS AS INHIBITORS OF ARACHIDONIC-ACID PEROXIDATION [J].

BAUMANN, J ;

BRUCHHAUSEN, FV ;

WURM, G .

PROSTAGLANDINS, 1980, 20 (04) :627-639

[2] PROSTAGLANDIN SYNTHETASE INHIBITION BY FLAVONOIDS AND PHENOLIC-COMPOUNDS IN RELATION TO THEIR O2-.-SCAVENGING PROPERTIES [J].

BAUMANN, J ;

WURM, G ;

BRUCHHAUSEN, FV .

ARCHIV DER PHARMAZIE, 1980, 313 (04) :330-337

[3] DISTRIBUTION AND METABOLISM OF ARACHIDONIC-ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS [J].

BLACKWELL, GJ ;

DUNCOMBE, WG ;

FLOWER, RJ ;

PARSONS, MF ;

VANE, JR .

BRITISH JOURNAL OF PHARMACOLOGY, 1977, 59 (02) :353-366

[4]

EGG D, 1984, Z RHEUMATOL, V43, P89

[5]

Gabor M., 1979, HDB EXP PHARM, V50, P698

[6] INFLUENCE OF EPILOBIUM EXTRACTS ON PROSTAGLANDIN BIOSYNTHESIS AND CARRAGEENAN INDUCED EDEMA OF THE RAT PAW [J].

HIERMANN, A ;

JUAN, H ;

SAMETZ, W .

JOURNAL OF ETHNOPHARMACOLOGY, 1986, 17 (02) :161-169

[7]

Hiermann A., 1985, SCI PHARM, V53, P39

[8]

Hiermann A., 1983, SCI PHARM, V51, P158

[9]

Hiermann A., 1987, SCI PHARM, V55, P111

[10] HORMONAL-STIMULATION OF ARACHIDONATE RELEASE FROM ISOLATED PERFUSED ORGANS - RELATIONSHIP TO PROSTAGLANDIN BIOSYNTHESIS [J].

ISAKSON, PC ;

RAZ, A ;

DENNY, SE ;

WYCHE, A ;

NEEDLEMAN, P .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1977, 14 (05) :853-871

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