EXTRAPITUITARY ACTION OF GONADOTROPIN-RELEASING HORMONE - DIRECT INHIBITION OF OVARIAN STEROIDOGENESIS

被引:348
作者
HSUEH, AJW
ERICKSON, GF
机构
关键词
D O I
10.1126/science.375393
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian Steroidogenesis. Copyright © 1979 AAAS.
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页码:854 / 855
页数:2
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