TISSUE DISTRIBUTION OF NEUTRAL ENDOPEPTIDASE-24.11 (ENKEPHALINASE) ACTIVITY IN GUINEA-PIG TRACHEA

被引：26

作者：

KUMMER, W

FISCHER, A

机构：

[1] Institute for Anatomy and Cell Biology I, University of Heidelberg, D-6900 Heidelberg

来源：

NEUROPEPTIDES | 1991年 / 18卷 / 04期

关键词：

D O I：

10.1016/0143-4179(91)90145-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The distribution of neutral endopeptidase 24.11 (NEP; 'enkephalinase') activity was studied on tissue sections of the guinea pig trachea using a histochemical method based on the catalytic activity of the enzyme. The specificity for NEP of the histochemical reaction was verified by application of an array of peptidase inhibitors. NEP activity was most prominent on the respiratory epithelium, but occurred also in submucous glands, connective tissue of the lamina propria, perichondrium and chondrocytes. The findings suggest that NEP in the trachea is involved in various functions, cleavage of neurally released peptides being only one of them.

引用

页码：181 / 186

页数：6

共 40 条

[1] BIOCHEMICAL AND IMMUNOLOGICAL PROPERTIES OF A MEMBRANE-BOUND BRAIN METALLOENDOPEPTIDASE - COMPARISON WITH THERMOLYSIN-LIKE KIDNEY NEUTRAL METALLOENDOPEPTIDASE [J].