ALTERATIONS OF SELECTED ENZYMES OF PHOSPHOLIPID-METABOLISM IN ALZHEIMERS-DISEASE BRAIN-TISSUE AS COMPARED TO NON-ALZHEIMERS DEMENTED CONTROLS

被引：33

作者：

KANFER, JN ^{[1
]}

PETTEGREW, JW ^{[1
]}

MOOSSY, J ^{[1
]}

MCCARTNEY, DG ^{[1
]}

机构：

[1] UNIV PITTSBURGH,WESTERN PSYCHIAT INST & CLIN,SCH MED,DEPT PATHOL,DEPT PSYCHIAT,PITTSBURGH,PA 15213

来源：

NEUROCHEMICAL RESEARCH | 1993年 / 18卷 / 03期

关键词：

ALZHEIMERS DISEASE; MEMBRANES; PHOSPHOLIPIDS; ENZYMES; GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASES;

D O I：

10.1007/BF00969091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have demonstrated elevated brain levels of phosphomonoesters in early stages of Alzheimer's disease and elevations of phosphodiesters later in the disease. In addition, preliminary quantitative analyses of the phospholipids of Alzheimer's brain reveals either decreases in some phospholipids or elevations followed by decreases in others. This study quantitated the activities of selected enzymes involved in phospholipid and choline metabolism and demonstrated elevated glycerol-3-phosphorylcholine phosphodiesterase and decreased choline kinase activities in Alzheimer's disease brain. The former could provide an enzymatic mechanism for the increased phosphorylcholine found in Alzheimer's disease brain.

引用

页码：331 / 334

页数：4

共 23 条

[1] A RAT-BRAIN CYTOSOLIC N-METHYLTRANSFERASE(S) ACTIVITY CONVERTING PHOSPHORYLETHANOLAMINE INTO PHOSPHORYLCHOLINE [J].