SURFACE-PROTEINS INVOLVED IN T-CELL COSTIMULATION

被引:98
作者
MONDINO, A
JENKINS, MK
机构
[1] Department of Microbiology, Minnesota University Medical School, Box 196 UMHC, Minneapolis, MN 55455
关键词
T CELL ANTIGEN RECEPTOR; CD28; B7; SIGNAL TRANSDUCTION; ANERGY; LYMPHOKINE MESSENGER-RNA;
D O I
10.1002/jlb.55.6.805
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The activation and eventual clonal expansion of individual antigen-specific CD4(+) T cell clones are dependent on the production of autocrine growth factors such as interleukin-2 (IL-2). The specificity of CD4(+) T cell activation is imparted by T cell antigen receptor (TCR) recognition of peptide antigens bound to class II major histocompatibility complex (MHC)-encoded molecules on the surface of antigen-presenting cells (APCs), for example B cells, macrophages, and dendritic cells. To induce maximal IL-2 production by T cells, however, APCs must also provide non-antigen-specific costimulatory signals. Recent work indicates that APC-derived costimulatory signals play a critical role in determining whether lymphokine production, apoptotic cell death, or functional anergy is induced by TCR engagement. This information has allowed immunologists to manipulate costimulatory molecules to prevent allograft rejection and enhance tumor immunity. Here we review current information on the biologic effects of, and signal transduction pathways engaged by, several known receptor-ligand pairs that transduce costimulatory signals in T cells. Special emphasis will be placed on the interaction of CD28 on the T cell with its ligands, B7-1, B7-2, and B7-3 on the APC.
引用
收藏
页码:805 / 815
页数:11
相关论文
共 107 条
[1]   COTRANSFECTION OF ICAM-1 AND HLA-DR RECONSTITUTES HUMAN ANTIGEN-PRESENTING CELL-FUNCTION IN MOUSE L-CELLS [J].
ALTMANN, DM ;
HOGG, N ;
TROWSDALE, J ;
WILKINSON, D .
NATURE, 1989, 338 (6215) :512-514
[2]   MOLECULAR-CLONING OF A CD28 CDNA BY A HIGH-EFFICIENCY COS CELL EXPRESSION SYSTEM [J].
ARUFFO, A ;
SEED, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8573-8577
[3]   CD28 INTERACTION WITH B7-COSTIMULATES PRIMARY ALLOGENEIC PROLIFERATIVE RESPONSES AND CYTOTOXICITY MEDIATED BY SMALL, RESTING LYMPHOCYTES-T [J].
AZUMA, M ;
CAYABYAB, M ;
BUCK, D ;
PHILLIPS, JH ;
LANIER, LL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (02) :353-360
[4]   B70 ANTIGEN IS A 2ND LIGAND FOR CTLA-4 AND CD28 [J].
AZUMA, M ;
ITO, D ;
YAGITA, H ;
OKUMURA, K ;
PHILLIPS, JH ;
LANIER, LL ;
SOMOZA, C .
NATURE, 1993, 366 (6450) :76-79
[5]   FUNCTIONAL EXPRESSION OF B7/BB1 ON ACTIVATED LYMPHOCYTES-T [J].
AZUMA, M ;
YSSEL, H ;
PHILLIPS, JH ;
SPITS, H ;
LANIER, LL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (03) :845-850
[6]  
BOHJANEN PR, 1992, J BIOL CHEM, V267, P6302
[7]   AN INDUCIBLE CYTOPLASMIC FACTOR (AU-B) BINDS SELECTIVELY TO AUUUA MULTIMERS IN THE 3' UNTRANSLATED REGION OF LYMPHOKINE MESSENGER-RNA [J].
BOHJANEN, PR ;
PETRYNIAK, B ;
JUNE, CH ;
THOMPSON, CB ;
LINDSTEN, T .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (06) :3288-3295
[8]   THE NFAT-1 DNA-BINDING COMPLEX IN ACTIVATED T-CELLS CONTAINS FRA-1 AND JUNB [J].
BOISE, LH ;
PETRYNIAK, B ;
MAO, XH ;
JUNE, CH ;
WANG, CY ;
LINDSTEN, T ;
BRAVO, R ;
KOVARY, K ;
LEIDEN, JM ;
THOMPSSON, CB .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1911-1919
[9]  
BOUSSIOTIS VA, 1993, P NATL ACAD SCI USA, V90, P11059, DOI 10.1073/pnas.90.23.11059
[10]   B7 BUT NOT INTERCELLULAR-ADHESION MOLECULE-1 COSTIMULATION PREVENTS THE INDUCTION OF HUMAN ALLOANTIGEN-SPECIFIC TOLERANCE [J].
BOUSSIOTIS, VA ;
FREEMAN, GJ ;
GRAY, G ;
GRIBBEN, J ;
NADLER, LM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) :1753-1763