ON THE SODIUM AND LITHIUM ION AFFINITIES OF SOME ALPHA-AMINO-ACIDS

被引：95

作者：

BOJESEN, G

BREINDAHL, T

ANDERSEN, UN

机构：

[1] Department of Chemistry, Odense University, Odense M

来源：

ORGANIC MASS SPECTROMETRY | 1993年 / 28卷 / 12期

关键词：

D O I：

10.1002/oms.1210281215

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The decomposition of 59 different cluster ions (generated by fast atom bombardment) consisting of two different amino acids and a sodium ion was analysed. The only fragment ions of significant abundance could be assigned to sodium ion-bound amino acids. Assuming that the most abundant ion in the fragment ion spectrum corresponds to the amino acid with the highest sodium ion affinity (SIA), the 20 common alpha-amino acids could be ordered with increasing sodium ion affinity as follows: Gly, Ala, Cys, Val, (Leu, Ile), Ser, Met, Thr, (Phe, Pro), Asp, Tyr, (Glu, Lys), Trp, Asn, Gln, His, Arg. Quantitative determinations were carried out by comparison of the lithium ion affinity (LIA) of Ala with that of dimethylformamide (DMF) in a fragment ion scan of the ion-bound dimer Ala-Li+-DMF. LIA(Ala) was calculated from LIA(Ala) = LIA(DMF) -(1/C)ln[I(AlaLa+)/I(DMF-Li+), where the constant C was estimated from measurements of proton-bound amine-amino acid clusters. From fragment ion analysis of nine other Li+-bound alpha-amino acid dimers, the following lithium ion affinities were obtained: Gly 51.0, Ala 52.6, Sar 53.5, alpha-aminobutyric acid 53.7, glycine methyl ester 54.7 and Val 54.8. SIA(Ala) was estimated to be 75% of the lithium ion affinity and from fragment ion analysis of ten Na+-bound alpha-amino acid dimers the following sodium ion affinities were obtained: Gly 37.9, Ala 39.4, alpha-aminobutyric acid 40.3, Val 41.0, glycine methylster 41.0 and Sar 41.2.

引用

页码：1448 / 1452

页数：5

共 38 条

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