SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-DEACETOXYPACLITAXEL

被引：32

作者：

CHORDIA, MD

CHAUDHARY, AG

KINGSTON, DGI

JIANG, YQ

HAMEL, E

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

[2] NCI,DIV CANC TREATMENT,MOLEC PHARMACOL LAB,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 37期

关键词：

D O I：

10.1016/0040-4039(94)85019-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Deacetoxypaclitaxel (9) has been prepared in seven steps from paclitaxel (Taxol(R)). It is significantly less active than paclitaxel in tubulin-assembly and cytotoxicity bioassays.

引用

页码：6843 / 6846

页数：4

共 21 条

[1] NEW METHOD FOR DEOXYGENATION OF SECONDARY ALCOHOLS
BARTON, DHR
MCCOMBIE, SW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1975, (16): : 1574 - 1585
[2] BLECHERT S, 1990, ALKALOIDS CHEM PHARM, V39, P195
[3] UNEXPECTEDLY FACILE HYDROLYSIS OF THE 2-BENZOATE GROUP OF TAXOL AND SYNTHESES OF ANALOGS WITH INCREASED ACTIVITIES
CHAUDHARY, AG
GHARPURE, MM
RIMOLDI, JM
CHORDIA, MD
GUNATILAKA, AAL
KINGSTON, DGI
GROVER, S
LIN, CM
HAMEL, E
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (09) : 4097 - 4098
[4] TAXOL STRUCTURE-ACTIVITY-RELATIONSHIPS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-DEOXYTAXOL
CHEN, SH
WEI, JM
FARINA, V
[J]. TETRAHEDRON LETTERS, 1993, 34 (20) : 3205 - 3206
[5] PHASE-II TRIAL OF TAXOL, AN ACTIVE-DRUG IN THE TREATMENT OF METASTATIC BREAST-CANCER
HOLMES, FA
WALTERS, RS
THERIAULT, RL
FORMAN, AD
NEWTON, LK
RABER, MN
BUZDAR, AU
FRYE, DK
HORTOBAGYI, GN
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (24) : 1797 - 1805
[6] FIRST TOTAL SYNTHESIS OF TAXOL .2. COMPLETION OF THE C-RING AND D-RING
HOLTON, RA
KIM, HB
SOMOZA, C
LIANG, F
BIEDIGER, RJ
BOATMAN, PD
SHINDO, M
SMITH, CC
KIM, SC
NADIZADEH, H
SUZUKI, Y
TAO, CL
VU, P
TANG, SH
ZHANG, PS
MURTHI, KK
GENTILE, LN
LIU, JH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (04) : 1599 - 1600
[7] THE CHEMISTRY OF TAXOL, A CLINICALLY USEFUL ANTICANCER AGENT
KINGSTON, DGI
SAMARANAYAKE, G
IVEY, CA
[J]. JOURNAL OF NATURAL PRODUCTS, 1990, 53 (01): : 1 - 12
[8] TAXOL - THE CHEMISTRY AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL ANTICANCER AGENT
KINGSTON, DGI
[J]. TRENDS IN BIOTECHNOLOGY, 1994, 12 (06) : 222 - 227
[9] THE CHEMISTRY OF TAXOL
KINGSTON, DGI
[J]. PHARMACOLOGY & THERAPEUTICS, 1991, 52 (01) : 1 - 34
[10] KINGSTON DGI, 1993, PROG CHEM ORG NAT PR, V61, P1

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