SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-DEACETOXYPACLITAXEL

被引:32
作者
CHORDIA, MD
CHAUDHARY, AG
KINGSTON, DGI
JIANG, YQ
HAMEL, E
机构
[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061
[2] NCI,DIV CANC TREATMENT,MOLEC PHARMACOL LAB,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892
关键词
D O I
10.1016/0040-4039(94)85019-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
4-Deacetoxypaclitaxel (9) has been prepared in seven steps from paclitaxel (Taxol(R)). It is significantly less active than paclitaxel in tubulin-assembly and cytotoxicity bioassays.
引用
收藏
页码:6843 / 6846
页数:4
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