PERINATAL MEASLES INFECTION AND SUBSEQUENT CROHNS-DISEASE

被引:130
作者
EKBOM, A
WAKEFIELD, AJ
ZACK, M
ADAMI, HO
机构
[1] HARVARD UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL,BOSTON,MA 02115
[2] ROYAL FREE HOSP,SCH MED,INFLAMMATORY BOWEL DIS STUDY GRP,LONDON,ENGLAND
[3] CTR DIS CONTROL & PREVENT,NATL CTR CHRON DIS PREVENT & HLTH PROMOT,ATLANTA,GA 30341
关键词
D O I
10.1016/S0140-6736(94)91898-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although the aetiology of Crohn's disease is unknown, morphological and epidemiological studies have implicated measles virus as a potential component cause, particularly when exposure occurs in utero or early in life. An increased incidence of Crohn's disease among people born during measles epidemics would support this hypothesis. We identified all individuals born in four counties in central Sweden in 1945-54 who had had Crohn's disease diagnosed before the age of 30 years. Yearly reports compiled in these counties revealed that five measles epidemics had affected all four counties during the trial period. After adjusting for monthly differences in the number of livebirths in the four counties, we calculated the expected number of patients with Crohn's disease and ulcerative colitis born during the 3-month period after the peaks of the epidemics. The number of people with Crohn's disease significantly exceeded that expected: 57 versus 39.0 (standardised incidence ratio 1.46, 95% CI 1.11-1.89). For patients with ulcerative colitis, the observed number (42) was close to that expected (46.8). Our results strengthen the hypothesis that measles is related to Crohn's disease and that the perinatal period is a time of vulnerability.
引用
收藏
页码:508 / 510
页数:3
相关论文
共 17 条
  • [1] AABY P, 1988, LANCET, V1, P516
  • [2] PERINATAL RISK-FACTORS FOR INFLAMMATORY BOWEL-DISEASE - A CASE-CONTROL STUDY
    EKBOM, A
    ADAMI, HO
    HELMICK, CG
    JONZON, A
    ZACK, MM
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 132 (06) : 1111 - 1119
  • [3] THE EPIDEMIOLOGY OF INFLAMMATORY BOWEL-DISEASE - A LARGE, POPULATION-BASED STUDY IN SWEDEN
    EKBOM, A
    HELMICK, C
    ZACK, M
    ADAMI, HO
    [J]. GASTROENTEROLOGY, 1991, 100 (02) : 350 - 358
  • [4] IS THERE CLUSTERING OF INFLAMMATORY BOWEL-DISEASE AT BIRTH
    EKBOM, A
    ZACK, M
    ADAMI, HO
    HELMICK, C
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1991, 134 (08) : 876 - 886
  • [5] AN EPIDEMIOLOGICAL STUDY OF ULCERATIVE COLITIS AND REGIONAL ENTERITIS IN OXFORD AREA
    EVANS, JG
    ACHESON, ED
    [J]. GUT, 1965, 6 (04) : 311 - &
  • [6] GARLAND CF, 1981, GASTROENTEROLOGY, V81, P1115
  • [7] CROHNS DISEASE (REGIONAL ENTERITIS) OF THE LARGE INTESTINE AND ITS DISTINCTION FROM ULCERATIVE COLITIS
    LOCKHARTMUMMERY, HE
    MORSON, BC
    [J]. GUT, 1960, 1 (02) : 87 - 105
  • [8] LUNDEE AS, 1980, DHHS PHS801358 PUBL
  • [9] MORGAN KL, 1987, LANCET, V1, P1017
  • [10] NORLEN BJ, 1970, SCAND J GASTROENTERO, V5, P385