STRUCTURE OF THE PROMOTER FOR THE HUMAN MACROPHAGE STIMULATING PROTEIN-RECEPTOR GENE

被引：14

作者：

DELGATTO, F ^{[1
]}

GILBERT, E ^{[1
]}

RONSIN, C ^{[1
]}

BREATHNACH, R ^{[1
]}

机构：

[1] CHR,INST BIOL,INSERM,U211,F-44035 NANTES 01,FRANCE

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1263卷 / 01期

关键词：

PROMOTER; MSP; RON;

D O I：

10.1016/0167-4781(95)00082-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The macrophage stimulating protein receptor is a receptor protein tyrosine kinase of the met/hepatocyte growth factor receptor family. Binding of the macrophage stimulating protein to its receptor provokes changes in cell morphology and motility. Here we report the structure of the promoter of the gene coding for this receptor. The major transcription start sites have been identified. The 5' flanking region has characteristics of other receptor tyrosine kinase gene promoters, namely several GC boxes but the absence of a TATA box. Deletion analysis shows that multiple elements are needed for full promoter activity.

引用

页码：93 / 95

页数：3

共 11 条

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[2] THE RETINOBLASTOMA GENE-PRODUCT RB STIMULATES SP1-MEDIATED TRANSCRIPTION BY LIBERATING SP1 FROM A NEGATIVE REGULATOR [J].