DOSE-DEPENDENT PHARMACOKINETICS OF ACETAMINOPHEN - EVIDENCE OF GLUTATHIONE DEPLETION IN HUMANS

被引:113
作者
SLATTERY, JT [1 ]
WILSON, JM [1 ]
KALHORN, TF [1 ]
NELSON, SD [1 ]
机构
[1] UNIV WASHINGTON,DEPT MED CHEM,SEATTLE,WA 98195
关键词
D O I
10.1038/clpt.1987.50
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:413 / 418
页数:6
相关论文
共 30 条
[1]  
ALBANO E, 1985, MOL PHARMACOL, V28, P306
[2]   N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].
DAHLIN, DC ;
MIWA, GT ;
LU, AYH ;
NELSON, SD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331
[3]  
DAVIS M, 1976, Q J MED, V45, P181
[4]   CLINICAL PHARMACOKINETICS OF PARACETAMOL [J].
FORREST, JAH ;
CLEMENTS, JA ;
PRESCOTT, LF .
CLINICAL PHARMACOKINETICS, 1982, 7 (02) :93-107
[5]   EFFECT OF SODIUM-SULFATE ON ACETAMINOPHEN ELIMINATION BY RATS [J].
GALINSKY, RE ;
SLATTERY, JT ;
LEVY, G .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (06) :803-805
[6]   EFFECT OF N-ACETYLCYSTEINE ON THE PHARMACOKINETICS OF ACETAMINOPHEN IN RATS [J].
GALINSKY, RE ;
LEVY, G .
LIFE SCIENCES, 1979, 25 (08) :693-700
[7]  
GEMBORYS MW, 1981, DRUG METAB DISPOS, V9, P340
[8]   DRUG BIOTRANSFORMATION INTERACTIONS IN MAN .6. ACETAMINOPHEN AND ASCORBIC-ACID [J].
HOUSTON, JB ;
LEVY, G .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1976, 65 (08) :1218-1221
[9]  
JAKOBY WB, 1982, SULPHATE METABOLISM, P13
[10]   ACETAMINOPHEN-INDUCED HEPATIC NECROSIS .6. METABOLIC DISPOSITION OF TOXIC AND NONTOXIC DOSES OF ACETAMINOPHEN [J].
JOLLOW, DJ ;
THORGEIRSSON, SS ;
POTTER, WZ ;
HASHIMOTO, M ;
MITCHELL, JR .
PHARMACOLOGY, 1974, 12 (4-5) :251-271