PROGNOSTIC-SIGNIFICANCE OF SURFACE MARKER EXPRESSION ON BLASTS OF PATIENTS WITH DENOVO ACUTE MYELOBLASTIC-LEUKEMIA

The prognostic significance of the expression of surface membrane antigens on the blasts of 123 consecutive patients with de novo acute myeloblastic leukemia (AML) was evaluated. For this purpose, reactivity of monoclonal antibodies (mAbs) CLB-ERY3 (antiblood-group H antigen), VIM-D5 (CD15), WT1 (CD7), MY7 (CD 13), MY9 (CD33), VID-1 (antihuman leukocyte antigen locus DR [anti-HLA DR]), VIM-2 (CDw65L), VIM-13(CD14), 63D3(CD14)andanti-TdT with leukemic blast cell populations was prospectively analyzed with respect to the rates of complete remission (CR), continuous complete remission (CCR), and survival. The overall rate of CR was 65%, the 6-year rates of overall CCR and survival were 23% and 13%, respectively (median period of patient observation, 30 months). Of all Abs tested, four (CLB-ERY3, MY7, anti-TdT, and VIM-D5) were found to be of prognostic value. Reactivity of CLB-ERY3, MY7, and anti-TdT was predictive for CR (CLB-ERY3+, 43% v CLB-ERY3-, 73%, P < .02; MY7+, 59% v MY7-, 91%, P < .003; TdT+, 28% v TdT-, 71%, P < .001, respectively) and probability of survival (significantly lower survival rates: CLB-ERY3+, P < .02; MY7+, P < .03; and TdT+ cases, P < .001, respectively). Reactivity of VIM-D5 was significantly associated with a higher probability of CCR (P < .01). Our results confirm earlier reports on the prognostic significance of expression of CD13 and TdT in AMI and indicate CLB-ERY3 (antiblood-group H antibody) and VIM-D5 (CD 15) as further markers predictive for the clinical outcome in patients with de nova AMI. © 1990 by American Society of Clinical Oncology.