BINDING OF EPIDERMAL GROWTH-FACTOR TO PRIMARY AND PERMANENT CULTURES OF MOUSE EPIDERMAL-CELLS - INHIBITION BY TUMOR-PROMOTING PHORBOL ESTERS

被引：38

作者：

MURRAY, AW

FUSENIG, NE

机构：

[1] GERMAN CANC RES CTR,INST BIOCHEM,D-6900 HEIDELBERG 1,FED REP GER

[2] FLINDERS UNIV S AUSTRALIA,SCH BIOL SCI,BEDFORD PK 5042,S AUSTRALIA,AUSTRALIA

来源：

CANCER LETTERS | 1979年 / 7卷 / 2-3期

关键词：

D O I：

10.1016/S0304-3835(79)80098-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High affinity binding of epidermal growth factor (EGF) was detected with mouse epidermal cells in primary culture and with 2 epidermal cell lines maintained in permanent culture. EGF binding was inhibited by low concentrations of the tumor promoters 12-O-tetradecanoyl phorbol-13-acetate (TPA) and phorbol didecanoate (PDD), but not by the non-promoting phorbol esters 4-O-methyl TPA and 4α-PDD. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

引用

页码：71 / 77

页数：7

共 25 条

[1]

BAIRD WM, 1971, CANCER RES, V31, P1334

[2]

Boutwell R K, 1974, CRC Crit Rev Toxicol, V2, P419

[3] REGULATION OF CELL-PROLIFERATION - ADVANCES IN BIOLOGY AND MECHANISM OF ACTION OF EPIDERMAL GROWTH-FACTOR [J].