PROBING THE TOPOGRAPHY OF KAINATE RECOGNITION SITES - SYNTHESIS OF A NOVEL OXETANE CONTAINING KAINIC ACID ANALOG

被引：29

作者：

KOZIKOWSKI, AP ^{[1
]}

FAUQ, AH ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT BEHAV NEUROSCI,PITTSBURGH,PA 15260

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(00)89000-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short synthesis of the conformationally rigidified spirocyclic-kainic acid analogue 2 is described starting from kainic acid. This relatively conservative change in the structure of kainic acid has been found to lead to a loss of affinity for glutamate recognition sites. © 1990.

引用

页码：2967 / 2970

页数：4

共 14 条

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