HEXADECYLPHOSPHOCHOLINE IN THE TOPICAL TREATMENT OF SKIN METASTASES IN BREAST-CANCER PATIENTS

被引:45
作者
UNGER, C
PEUKERT, M
SINDERMANN, H
HILGARD, P
NAGEL, G
EIBL, H
机构
[1] MAX PLANCK INST BIOPHYS CHEM,W-3400 GOTTINGEN,GERMANY
[2] ASTA PHARMA AG,DEPT CANC RES & DEV,FRANKFURT,GERMANY
关键词
D O I
10.1016/0305-7372(90)90054-J
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Widespread local recurrence of breast cancer, untreatable by surgery or radiation therapy, can present a serious therapeutic problem predominantly in patients refractory to systemic therapy. In a phase I trial hexadecylphosphocholine, a new agent with high membrane affinity and antineoplastic activity was applied topically to affected skin areas of breast cancer patients. The results provide evidence that hexadecylphosphocholine may be an active agent in the topical treatment of skin metastases. © 1990.
引用
收藏
页码:243 / 246
页数:4
相关论文
共 7 条
  • [1] A GENERAL SYNTHETIC METHOD FOR ENANTIOMERICALLY PURE ESTER AND ETHER LYSOPHOSPHOLIPIDS
    EIBL, H
    WOOLLEY, P
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 1988, 47 (01) : 63 - 68
  • [2] CHARACTERIZATION OF THE ANTITUMOR-ACTIVITY OF HEXADECYLPHOSPHOCHOLINE (D-18506)
    HILGARD, P
    STEKAR, J
    VOEGELI, R
    ENGEL, J
    SCHUMACHER, W
    EIBL, H
    UNGER, C
    BERGER, MR
    [J]. EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1988, 24 (09): : 1457 - 1461
  • [3] ALKYL PHOSPHOCHOLINES - TOXICITY AND ANTICANCER PROPERTIES
    MUSCHIOL, C
    BERGER, MR
    SCHULER, B
    SCHERF, HR
    GARZON, FT
    ZELLER, WJ
    UNGER, C
    EIBL, HJ
    SCHMAHL, D
    [J]. LIPIDS, 1987, 22 (11) : 930 - 934
  • [4] BLOOD-BRAIN-BARRIER AND PENETRATION OF CYTOSTATICS
    UNGER, C
    EIBL, H
    VONHEYDEN, HW
    KRISCH, B
    NAGEL, GA
    [J]. KLINISCHE WOCHENSCHRIFT, 1985, 63 (12): : 565 - 571
  • [5] HEXADECYLPHOSPHOCHOLINE (D-18506) IN THE TOPICAL TREATMENT OF SKIN METASTASES - A PHASE-I TRIAL
    UNGER, C
    EIBL, H
    BREISER, A
    VONHEYDEN, HW
    ENGEL, J
    HILGARD, P
    SINDERMANN, H
    PEUKERT, M
    NAGEL, GA
    [J]. ONKOLOGIE, 1988, 11 (06): : 295 - 296
  • [6] UNGER C, 1989, MONOGRAPHIE, P1
  • [7] WAGNER A, 1989, THESIS MED FAKULTAT