SYNTHESIS OF A POTENT ALPHA-GLUCOSIDASE INHIBITOR EPIMERIC TO FR-900483

被引：32

作者：

WITTE, JF

MCCLARD, RW

机构：

[1] Arthur F. Scott Laboratory of Chemistry, Reed College, Portland

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 32期

关键词：

D O I：

10.1016/0040-4039(91)80591-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The dihydropyrrole 2 was synthesized in four steps from a protected lyxose derivative. This compound exists as one component of a complex equilibrium that may also contain the hydrated forms, 7, as well as a dimeric form. The mixture comprises a potent inhibitor of yeast alpha-glucosidase (K(i) approximately 10(-7) M).

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页码：3927 / 3930

页数：4

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