EVIDENCE FOR INVOLVEMENT OF N-METHYL-D-ASPARTATE RECEPTOR IN TONIC INHIBITORY CONTROL OF DOPAMINERGIC TRANSMISSION IN RAT MEDIAL FRONTAL-CORTEX

被引:43
作者
HATA, N [1 ]
NISHIKAWA, T [1 ]
UMINO, A [1 ]
TAKAHASHI, K [1 ]
机构
[1] NATL CTR NEUROBIOL PSYCHIAT, NATL INST NEUROSCI, DIV MENTAL DISORDER RES, KODAIRA, TOKYO 187, JAPAN
关键词
3,4-Dihydroxyphenylacetic acid; Dopamine; Dopamine utilization; Excitatory amino acidergic transmission; Medial frontal cortex; N-Methyl-d-aspartate receptor; Norepinephrine utilization;
D O I
10.1016/0304-3940(90)90178-C
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Bilateral infusion of dl-2-amino-5-phosphonovalerate (dl-APV) (which is a competitive antagonist for N-methyl-d-aspartate (NMDA) receptor) into the medial frontal cortex of conscious rats increased the amount of 3,4-dihydroxyphenylacetic acid (DOPAC) and the DOPAC/dopamine (DA) ratio in the cortical area. Moreover, intra-prefrontal injection of dl-APV, d-APV, dl-2-amino-7-phosphonoheptanoate and 3-[(±)-2-carboxypiperazin-4-yl]-propyl-1-phosphonate (which are selective NMDA receptor antagonists), but not the l-isomer of APV and γ-glutamyl-aminomethyl sulphonate (a relative antagonist for non-NMDA receptors), facilitated prefrontal DA utilization in a NMDA-reversible manner. These findings suggest that NMDA-type excitatory amino acid receptors may be involved in a tonic inhibitory regulation of dopaminergic transmission in the medial frontal cortex in vivo. © 1990.
引用
收藏
页码:101 / 104
页数:4
相关论文
共 21 条
[1]   MODULATION OF DENDRITIC RELEASE OF DOPAMINE BY N-METHYL-D-ASPARTATE RECEPTORS IN RAT SUBSTANTIA NIGRA [J].
ARANEDA, R ;
BUSTOS, G .
JOURNAL OF NEUROCHEMISTRY, 1989, 52 (03) :962-970
[2]  
Bjorklund A., 1984, HDB CHEM NEUROANATOM, V2, P55
[3]   DIFFERENTIAL CONTROL BY N-METHYL-D-ASPARTATE AND KAINATE OF STRIATAL DOPAMINE RELEASE INVIVO - A TRANS-STRIATAL DIALYSIS STUDY [J].
CARTER, CJ ;
LHEUREUX, R ;
SCATTON, B .
JOURNAL OF NEUROCHEMISTRY, 1988, 51 (02) :462-468
[4]   INVIVO PRESYNAPTIC CONTROL OF DOPAMINE RELEASE IN THE CAT CAUDATE-NUCLEUS .2. FACILITATORY OR INHIBITORY INFLUENCE OF L-GLUTAMATE [J].
CHERAMY, A ;
ROMO, R ;
GODEHEU, G ;
BARUCH, P ;
GLOWINSKI, J .
NEUROSCIENCE, 1986, 19 (04) :1081-1090
[5]  
CLOW DW, 1989, J PHARMACOL EXP THER, V248, P722
[6]  
COLLINGRIDGE GL, 1989, PHARMACOL REV, V41, P143
[7]  
COTMAN CW, 1987, PSYCHOPHARMACOLOGY 3, P197
[8]   INHIBITION BY PHENCYCLIDINE OF EXCITATORY AMINO ACID-STIMULATED RELEASE OF NEUROTRANSMITTER IN THE NUCLEUS-ACCUMBENS [J].
JONES, SM ;
SNELL, LD ;
JOHNSON, KM .
NEUROPHARMACOLOGY, 1987, 26 (2-3) :173-179
[9]  
Konig JFR, 1963, RAT BRAIN STEREOTAXI
[10]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265