AEROSOLIZED DRUG DELIVERY - FRACTIONAL DEPOSITION OF INHALED PARTICLES

被引：8

作者：

BENNETT, WD

机构：

[1] Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1991年 / 4卷 / 03期

关键词：

AEROSOLS; DEPOSITION; AEROSOL DRUG DELIVERY;

D O I：

10.1089/jam.1991.4.223

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Delivery of drugs by aerosol is increasingly used as a means of providing therapy to both the lungs and to the rest of the body through absorption into the pulmonary circulation. The techniques, definitions, and terminology for aerosol delivery are not standardized or necessarily understood by the increasing number of clinicians and clinical investigators involved in these studies. This paper attempts to establish some definitions and guidelines for defining and characterizing deposition of aerosols in the respiratory tract. Some of the parameters that affect deposition are discussed (e.g., particle size, breathing pattern, airway caliber). It is suggested that these parameters be controlled or measured when characterizing new aerosol delivery systems for clinical investigations. These recommendations were discussed and agreed upon during an expert meeting on definitions and standards related to aerosols in medicine at the 8th Congress of ISAM. © 1991, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：223 / 227

页数：5

共 12 条

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