MEASUREMENTS OF BLOOD-BRAIN-BARRIER PERMEABILITY IN PATIENTS UNDERGOING RADIOTHERAPY AND CHEMOTHERAPY FOR PRIMARY CEREBRAL LYMPHOMA

被引：86

作者：

OTT, RJ

BRADA, M

FLOWER, MA

BABICH, JW

CHERRY, SR

DEEHAN, BJ

机构：

[1] ROYAL MARSDEN HOSP,ACAD UNIT RADIOTHERAPY & ONCOL,SUTTON SM2 5PT,SURREY,ENGLAND

[2] ROYAL MARSDEN HOSP,INST CANC RES,SUTTON SM2 5PT,SURREY,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 11期

关键词：

D O I：

10.1016/0277-5379(91)90009-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Positron emission tomography (PET) has been used to measure changes in regional blood-brain barrier (BBB) permeability in patients with primary cerebral lymphoma undergoing radiotherapy and chemotherapy. The method employed is to measure the rate of wash-out of a radioactive tracer (Ga-68-EDTA) from blood into brain tissue using time-sequence PET imaging. Preliminary studies carried out on patients with more common primary cerebral tumours show that time-activity data are reproducible to approximately 10%. Measurements made in 2 patients with primary cerebral lymphoma treated with initial chemotherapy showed significant changes in permeability in the region of the tumour. Within 5 weeks of the start of treatment, permeability values reached the levels of normal brain. No changes in BBB permeability in normal brain were seen immediately after radiotherapy.

引用

页码：1356 / 1361

页数：6

共 14 条

[1] MANAGEMENT OF PRIMARY CEREBRAL LYMPHOMA WITH INITIAL CHEMOTHERAPY - PRELIMINARY-RESULTS AND COMPARISON WITH PATIENTS TREATED WITH RADIOTHERAPY ALONE [J].