CARBON-DIOXIDE INHALATION REDUCES THE FUNCTION OF GABA-A RECEPTORS IN THE RAT-BRAIN

被引：36

作者：

SANNA, E

CUCCHEDDU, T

SERRA, M

CONCAS, A

BIGGIO, G

机构：

[1] Department of Experimental Biology, University of Cagliari

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 03期

关键词：

CARBON DIOXIDE (CO2); GABA-A RECEPTORS; BRAIN (RAT);

D O I：

10.1016/0014-2999(92)90447-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of CO2 inhalation on the function of the GABA(A)-coupled chloride channel was evaluated in rat brain. This treatment decreased the capability of GABA to stimulate Cl-36 uptake and produced a significant increase of [S-35]-TBPS ([S-35]t-butylbicyclophosphorothionate) binding in the cerebral cortex, cerebellum and hippocampus. These results demonstrate that a brief exposure of rats to CO2 inhalation reduces the function of the GABA(A)-ionophore receptor complex in rat brain.

引用

页码：457 / 458

页数：2

共 5 条

[1] ENHANCEMENT OF GABAERGIC TRANSMISSION BY ZOLPIDEM, AN IMIDAZOPYRIDINE WITH PREFERENTIAL AFFINITY FOR TYPE-I BENZODIAZEPINE RECEPTORS [J].