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SEPARATION OF REDUCED AND OXIDIZED GLUTATHIONE IN A PHARMACEUTICAL PREPARATION BY ION-INTERACTION REVERSED-PHASE HPLC

被引：16
作者：
GENNARO, MC
ABRIGO, C
机构：
[1] Dipartimento di Chimica Analitica, Universita' di Torino, 10125 Torino, Via P. Giuria
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 01期
关键词：
ION-INTERACTION REVERSED-PHASE HPLC; GLUTATHIONE DETERMINATION; SEPARATION OF REDUCED AND OXIDIZED GLUTATHIONE; REDUCED GLUTATHIONE; ANTIOXIDANTS; RADICAL SCAVENGERS;
D O I：
10.1016/0731-7085(92)80011-B
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new method is presented for the simultaneous determination of reduced and oxidized glutathione by ion-interaction reversed-phase HPLC with octylamine orthophosphate as the interaction reagent, 5-mu-m Spherisorb ODS-2 as the stationary phase and UV detection at 230 nm. Lower limits of detection of 2.50-mu-g ml-1 have been achieved for both the oxidized and the reduced forms. The method has been applied in the analysis of a commercial pharmaceutical preparation.
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页码：61 / 65
页数：5
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