MOLECULAR MECHANISMS REGULATING CD19, CD20 AND CD22 GENE-EXPRESSION

被引：72

作者：

KEHRL, JH

RIVA, A

WILSON, GL

THEVENIN, C

机构：

[1] John H. Kehrl, Agostino Riva, Gaye Lynn Wilson and Claire Thévenin are in the Section of B Cell Molecular Immunology, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 09期

关键词：

D O I：

10.1016/0167-5699(94)90273-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CD19, CD20 and CD22 genes encode transmembrane proteins that are of vital importance to B-cell function. Similar to the immunoglobulin (Ig) genes, they are expressed in a lineage-specific and developmentally regulated manner. Here, John Kehrl and colleagues describe how an understanding of the transcriptional regulation of the CD19, CD20 and CD22 genes is leading to valuable insights into some of the important molecular events that occur in B-cell development and differentiation.

引用

页码：432 / 436

页数：5

共 13 条

[1] PAX-5 ENCODES THE TRANSCRIPTION FACTOR BSAP AND IS EXPRESSED IN LYMPHOCYTES-B, THE DEVELOPING CNS, AND ADULT TESTIS [J].