CORTICOSTEROIDS FOR THE ENHANCEMENT OF FETAL LUNG MATURITY - IMPACT ON THE GRAVIDA WITH PREECLAMPSIA AND THE HELLP-SYNDROME

被引：39

作者：

MAGANN, EF

MARTIN, RW

ISAACS, JD

BLAKE, PG

MORRISON, JC

MARTIN, JN

机构：

[1] Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi

来源：

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY | 1993年 / 33卷 / 02期

关键词：

D O I：

10.1111/j.1479-828X.1993.tb02374.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This study was undertaken to determine maternal impact of corticosteroids administered for the promotion of fetal lung maturity in mothers with the HELLP syndrome. Twenty-seven of 427 women with the HELLP syndrome treated between 1980-1991 received a full course of steroids prior to preterm delivery. This group was compared to 27 matched control patients with the HELLP syndrome who received no corticosteroids. Subjects were matched for maternal age, race, sex of the fetus, and severity of the HELLP syndrome. The antepartum platelet count stabilized or increased in 25 of 27 steroid-treated women in contrast to 0 of 15 control women (p < 0.00001). In comparison to control patients, LDH serum concentrations in steroid-treated patients stabilized or decreased and the SGOT/AST and SGPT/ALT stabilized or decreased during therapy (p < 0.005). The interval from delivery to platelet nadir in patients with Class III HELLP syndrome was shorter in the steroid-treated group (p < 0.008) than in untreated patients.

引用

页码：127 / 131

页数：5

共 16 条

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