EXPRESSION OF GLUTATHIONE-S-TRANSFERASE-PI IN HUMAN OVARIAN-CANCER AS AN INDICATOR OF RESISTANCE TO CHEMOTHERAPY

被引:85
作者
HAMADA, SI
KAMADA, M
FURUMOTO, H
HIRAO, T
AONO, T
机构
[1] Department of Obstetrics and Gynecology, School of Medicine, The University of Tokushima, Tokushima
关键词
D O I
10.1006/gyno.1994.1055
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Expression of glutathione S-transferase-pi (GST-pi) was examined immunohistochemically in relation to the response to chemotherapy with cisplatin in 61 patients with primary ovarian cancer who had not received any chemotherapy before surgery. GST-pi were detected in the cancer tissues of 33 patients (54.1%). Of 28 clinically measurable lesions after surgery, 10 of the 11 tumors (90.9%) showing positive GST-pi staining were drug resistant (no change or progressive disease), whereas 6 of the 17 tumors (35.3%) showing negative staining were drug resistant. This difference in the response rates of the two groups was significant (P < 0.005). The survival period of patients with GST-pi-positive tumors was also significantly shorter than that of those with GST-pi-negative tumors (P < 0.005). These data strongly suggest that GST-pi expression in tumor cells is related to drug resistance of patients with epithelial ovarian cancer and is a useful marker of a poor prognosis. (C) 1994 Academic Press, Inc.
引用
收藏
页码:313 / 319
页数:7
相关论文
共 30 条
[1]  
ARMSTRONG DK, 1992, CANCER RES, V52, P1416
[2]  
BATIST G, 1986, J BIOL CHEM, V261, P5544
[3]  
Broders AC, 1926, ARCH PATHOL LAB MED, V2, P376
[4]   IMMUNOHISTOCHEMICAL DEMONSTRATION OF GLUTATHIONE S-TRANSFERASES IN PRIMARY HUMAN BREAST CARCINOMAS [J].
CAIRNS, J ;
WRIGHT, C ;
CATTAN, AR ;
HALL, AG ;
CANTWELL, BJ ;
HARRIS, AL ;
HORNE, CHW .
JOURNAL OF PATHOLOGY, 1992, 166 (01) :19-25
[5]  
DULIK DM, 1987, DRUG METAB DISPOS, V15, P195
[6]  
EINHORN N, 1985, CANCER, V55, P2019, DOI 10.1002/1097-0142(19850501)55:9<2019::AID-CNCR2820550932>3.0.CO
[7]  
2-2
[8]  
FIGO Cancer Committee, 1986, GYNECOL ONCOL, V25, P383
[9]  
Jakoby W B, 1978, Adv Enzymol Relat Areas Mol Biol, V46, P383
[10]   INTERACTIONS OF BILIRUBIN AND OTHER LIGANDS WITH LIGANDIN [J].
KAMISAKA, K ;
LISTOWSKY, I ;
GATMAITAN, Z ;
ARIAS, IM .
BIOCHEMISTRY, 1975, 14 (10) :2175-2180