THE ROLE OF NITRIC-OXIDE IN THE NEUROPATHOLOGY IN SOMAN INTOXICATION

被引：5

作者：

BOUCHAUD, C ^{[1
]}

CHOLLATNAMY, A ^{[1
]}

DUSERRE, S ^{[1
]}

DELAMANCHE, IS ^{[1
]}

机构：

[1] CTR ETUD BOUCHET,F-91370 VERT LE PETIT,FRANCE

来源：

BRAIN RESEARCH | 1994年 / 660卷 / 02期

关键词：

CEREBRAL ENDOTHELIAL CELL; NITRIC OXIDE; NADPH-DIAPHORASE; NEURON; NEUROPATHOLOGY; SOMAN;

D O I：

10.1016/0006-8993(94)91296-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intoxication with organophosphorus (OF) anticholinesterase agents such as soman triggers irreversible lesions in some cerebral areas. Administration of soman at the LD 50 leads to an increased activity of NADPH-diaphorase (= NO-synthase) in the cerebral endothelial cells from the 6th hour after poisoning. This activity culminates after 24 h, whereas variations in this enzymatic activity are not easily detectable in NADPH-diaphorase positive neurons. Since soman triggers astrocytic oedema leading to a possible decrease in the local cerebral blood flow, it is likely that the induction of endothelial NO-synthase exerts an antagonistic effect, since NO is a vasodilator.

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页码：249 / 254

页数：6

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