DISPOSITION OF CLOZAPINE AND DESMETHYLCLOZAPINE IN SCHIZOPHRENIC-PATIENTS

被引：34

作者：

LIN, SK

CHANG, WH

CHUNG, MC

LAM, YWF

JANN, MW

机构：

[1] TAIPEI CITY PSYCHIAT CTR,BIOL PSYCHIAT LAB,TAIPEI 10510,TAIWAN

[2] UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,DIV CLIN PHARM,SAN ANTONIO,TX 78284

[3] UNIV TEXAS,COLL PHARM,AUSTIN,TX 78712

[4] MERCER UNIV,DEPT PHARM PRACTICE,ATLANTA,GA

[5] MERCER UNIV,DEPT PHARMACEUT SCI,ATLANTA,GA

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 34卷 / 04期

关键词：

D O I：

10.1002/j.1552-4604.1994.tb02000.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The disposition of the atypical clozapine and its desmethyl metabolite were evaluated in fourteen male chronic patients. A single 100 mg dose of clozapine was administered and blood sampling performed over the following 72 hours. The mean (SD) oral clearance and half-life of clozapine were 55.4 (29.7) L/hr and 13.7 (9.9) hours, respectively. The mean (SD) AUC for clozapine and desmethylclozapine was 2389.9 (1406) and 751.1 (622.9) ng.hr/mL, respectively. The elimination of the metabolite is rate limited by its formation from cloza-pine. A wide interpatient variability in clozapine and desmethylclozapine pharmacokinetics was observed.

引用

页码：318 / 324

页数：7

共 30 条

[1] CLOZAPINE - PHARMACOKINETIC INVESTIGATIONS AND BIOCHEMICAL EFFECTS IN MAN [J].