2 NOVEL TRITERPENOID PENTASACCHARIDES WITH AN UNUSUAL GLYCOSYL GLYCEROL SIDE-CHAIN FROM ARDISIA-CRENATA

被引：15

作者：

JIA, ZH ^{[1
]}

KOIKE, K ^{[1
]}

NIKAIDO, T ^{[1
]}

OHMOTO, T ^{[1
]}

机构：

[1] TOHO UNIV, SCH PHARMACEUT SCI, DEPT PHARMACOGNOSY, FUNABASHI, CHIBA 274, JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 41期

关键词：

D O I：

10.1016/S0040-4020(01)89300-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Two novel triterpenoid pentasaccharides, ardisicrenosides E and F, were isolated from the roots of Ardisia crenata. They are the first examples of a triterpenoid glycoside hybridized with a glycosyl glycerol. Their structures were mainly established on the basis of high field NMR studies. In addition, molecular mechanics and dynamics calculation studies showed that the lack of C-13 glycosylation shifts in the Rham alpha 1-->2G'lc beta and G'lc beta 1-->4Ara alpha fragments in ardisicrenoside E could be correlated with the distortion of the corresponding torsion angles. Both compounds exhibited moderate inhibitory activity on cAMP phosphodiesterase.

引用

页码：11853 / 11864

页数：12

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