HAMMETT ANALYSIS OF THE INHIBITION OF PANCREATIC CHOLESTEROL ESTERASE BY SUBSTITUTED PHENYL N-BUTYLCARBAMATE

被引：37

作者：

LIN, G

LAI, CY

机构：

[1] Department of Chemistry, National Chung-Hsing University, Taichung

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 34期

关键词：

D O I：

10.1016/0040-4039(95)01233-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Substituted phenyl-N-butylcarbamates (1) as active site-directed irreversible inhibitors of pancreatic cholesterol esterase are investigated for values of the dissociation constant (K-I), the carbamylation constant (k(2)), and the bimolecular rate constant (k(i)). Linear free energy relationships between -logK(I), logk(2), or logk(i) and substituent constant (sigma) are observed.

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页码：6117 / 6120

页数：4

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