ASCORBIC-ACID INHIBITS PROTEIN-TYROSINE PHOSPHATASES IN NIH 3T3 CELLS EXPRESSING HUMAN EPIDERMAL GROWTH-FACTOR RECEPTORS

被引：14

作者：

MONTEIRO, HP

IVASCHENKO, Y

FISCHER, R

STERN, A

机构：

[1] NYU MED CTR,DEPT PHARMACOL,NEW YORK,NY 10016

[2] FDN HEMOCTR SAO PAULO,SAO PAULO,SP,BRAZIL

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1993年 / 25卷 / 12期

关键词：

D O I：

10.1016/0020-711X(88)90317-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Physiological concentrations of ascorbic acid inhibited PTPase activity in HER 14 cells. 2. Higher concentrations of ascorbic acid produced a weaker inhibitory effect on PTPase activity in HER 14 cells. 3. EGF prevented the inhibitory effect of ascorbic acid on PTPase activity in HER 14 cells. 4. The inhibitory effect of physiological concentrations of ascorbic acid on PTPase activity depends on density of the cell culture, with less dense populations exhibiting greater inhibition of PTPase activity. 5. These observations suggest that ascorbic acid might have a modulatory role in cellular phosphorylation-dephosphorylation events.

引用

页码：1859 / 1864

页数：6

共 25 条

[1] ALEXANDER D R, 1990, New Biologist, V2, P1049
[2] BRAUGHLER JM, 1986, J BIOL CHEM, V261, P282
[3] THE LEUKOCYTE COMMON ANTIGEN (CD45) - A PUTATIVE RECEPTOR-LINKED PROTEIN TYROSINE PHOSPHATASE
CHARBONNEAU, H
TONKS, NK
WALSH, KA
FISCHER, EH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) : 7182 - 7186
[4] CHOJKIER M, 1989, J BIOL CHEM, V264, P16957
[5] PROTEIN TYROSINE PHOSPHATASES - A DIVERSE FAMILY OF INTRACELLULAR AND TRANSMEMBRANE ENZYMES
FISCHER, EH
CHARBONNEAU, H
TONKS, NK
[J]. SCIENCE, 1991, 253 (5018) : 401 - 406
[6] TYROSINE PHOSPHORYLATION IN T-CELLS IS REGULATED BY PHOSPHATASE-ACTIVITY - STUDIES WITH PHENYLARSINE OXIDE
GARCIAMORALES, P
MINAMI, Y
LUONG, E
KLAUSNER, RD
SAMELSON, LE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (23) : 9255 - 9259
[7] A TYR SER PROTEIN PHOSPHATASE ENCODED BY VACCINIA VIRUS
GUAN, KL
BROYLES, SS
DIXON, JE
[J]. NATURE, 1991, 350 (6316) : 359 - 362
[8] GUAN KL, 1991, J BIOL CHEM, V266, P17026
[9] HEFFETZ D, 1989, J BIOL CHEM, V264, P10126
[10] POINT MUTATION AT THE ATP BINDING-SITE OF EGF RECEPTOR ABOLISHES PROTEIN-TYROSINE KINASE-ACTIVITY AND ALTERS CELLULAR ROUTING
HONEGGER, AM
DULL, TJ
FELDER, S
VANOBBERGHEN, E
BELLOT, F
SZAPARY, D
SCHMIDT, A
ULLRICH, A
SCHLESSINGER, J
[J]. CELL, 1987, 51 (02) : 199 - 209

← 1 2 3 →