N-DIALKYLAMINOALKYLBIPHENYLAMINES AS ANTIMALARIAL AND ANTISCHISTOSOMAL AGENTS

A series of N-dialkylaminoalkylbiphenylamines and N′-substituted N-biphenylpiperazines have been prepared and evaluated as antimalarial and antischistosomal agents. Potentially general procedures were developed for constructing four- and six-carbon aminoalkyl chains on the biphenylamine nuclei, utilizing succinic anhydride and 6-bromohexanoic acid, respectively. No important effects against experimental Plasmodium berghei or Schistosoma mansoni infections in mice were observed, but several of the compounds displayed significant in vitro activity against a series of nonparasitic microorganisms. © 1969, American Chemical Society. All rights reserved.