AMINOACYL NUCLEOSIDES DERIVED FROM TUMOUR INHIBITOR, 1-AMINOCYCLOPENTANE-CARBOXYLIC ACID

The 2′(3′)-O-adenosine and -uridine esters of 1-aminocylopentanecarboxylic acid have been prepared. They had no significant effect against an experimental plasma cell tumour in mice, nor did they inhibit protein synthesis in vitro. Each aminoacyl derivative was separated into its two components which were characterized by n.m.r. spectroscopy. No interconversion between the 2′- and 3′-substituted nucleosides occurred, although base catalyzed hydrolosis proceeded at a rate comparable with that of other aminoacyl nucleosides. The possible implications of these findings in protein biosynthesis are discussed. Some related compounds derived from 6-(methylthio) purine are described. © 1969.