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PLASTICITY OF THE PEPTIDERGIC MEDIATION OF SPINAL REFLEX FACILITATION AFTER PERIPHERAL-NERVE SECTION IN THE RAT

被引：43
作者：
WIESENFELDHALLIN, Z
XU, XJ
HAKANSON, R
FENG, DM
FOLKERS, K
机构：
[1] UNIV LUND,DEPT PHARMACOL,S-22101 LUND,SWEDEN
[2] UNIV TEXAS,INST BIOMED RES,AUSTIN,TX 78712
来源：
NEUROSCIENCE LETTERS | 1990年 / 116卷 / 03期
关键词：
Antagonist; Flexor reflex; Spinal cord; Substance P; Tachykinin; Unmyelinated afferent; Vasoactive intestinal peptide;
D O I：
10.1016/0304-3940(90)90089-R
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of the tachykinin antagonist Spantide II (d-Nic-Lys1,3-Pal3,d-Cl2Phe5,Asn6d-Trp7,9,Nle11)-substance P (SP) and the vasoactive intestinal peptide (VIP) antagonist (Ac-Tyr1,d-Phe2)-GRF(1-29)-NH2 on the excitability of the spinal nociceptive flexor reflex to intrathecally (i.t.) applied SP and VIP, respectively, as well as the facilitation evoked by activation of cutaneous C-afferent was examined. Both antagonists blocked the effects of the respective neuropeptides in rats with both intact and sectioned sciatic nerves. Spantide II antagonised C-afferent induced reflex facilitation in rats with intact nerves, but the degree of antagonism declined after axotomy. In contrast, the VIP antagonist did not block C-afferent induced facilitation in rats with intact nerves, but did so after axotomy. The results indicate that the role of tachykinins in mediating C-afferent-induced reflex facilitation is taken over by VIP after axotomy. © 1990.
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页码：293 / 298
页数：6
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