ETHANOL AND THE NMDA RECEPTOR

被引：124

作者：

HOFFMAN, PL

RABE, CS

GRANT, KA

VALVERIUS, P

HUDSPITH, M

TABAKOFF, B

机构：

[1] National Inst. on Alcohol Abuse and Alcoholism Deivision of Intramural Clinical and Biological Resea, Bethesda

来源：

ALCOHOL | 1990年 / 7卷 / 03期

关键词：

Calcium influx; Cyclic GMP; Ethanol; Ethanol withdrawal seizures; Glutamate; MK-801; binding; NMDA receptor;

D O I：

10.1016/0741-8329(90)90010-A

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic ethanol ingestion, the number of NMDA receptor-ion channel complexes in certain brain areas is increased. This increase may contribute to the generation of ethanol withdrawal seizures, since administration of an NMDA receptor antagonist can reduce these seizures. The results suggest that certain acute behavioral effects of ethanol, such as effects on memory, as well as certain aspects of ethanol withdrawal, may involve the NMDA receptor. © 1990.

引用

页码：229 / 231

页数：3

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