PARALLEL INVESTIGATIONS OF THE EFFECTS OF ADENOSINE ON EVOKED-POTENTIALS AND CYCLIC-AMP ACCUMULATION IN HIPPOCAMPUS SLICES OF THE RAT

被引:38
作者
REDDINGTON, M
SCHUBERT, P
机构
[1] Max-Planck-Institute for Psychiatry, 8000 Munich 40
关键词
D O I
10.1016/0304-3940(79)95340-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In slices of rat hippocampus, adenosine and its receptor agonist, 2-chloro-adenosine, were both found to (a) enhance the intracellular accumulation of cyclic adenosine monophosphate (cAMP) and (b) depress neuronal evoked responses to electrical stimulation. The differences in the dose/effect curves for the biochemical and electrophysiological changes cast doubt on a causal relationship between the two effects. © 1979.
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页码:37 / 42
页数:6
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