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POSTISCHEMIC TREATMENT WITH HYPOTHERMIA IMPROVES OUTCOME FROM INCOMPLETE CEREBRAL-ISCHEMIA IN RATS
被引：14
作者：
HOFFMAN, WE
WERNER, C
BAUGHMAN, VL
THOMAS, C
MILETICH, DJ
ALBRECHT, RF
机构：
[1] Department of Anesthesiology, Michael Reese Hospital and Medical Center, University of Illinois Medical School, Chicago, IL
[2] Department of Pathology, Michael Reese Hospital and Medical Center, University of Illinois Medical School, Chicago, IL
[3] Department of Anesthesiology, University Hospital Eppendorf, Hamburg
关键词：
BRAIN ISCHEMIA;
BRAIN METABOLISM;
ANESTHETICS;
INHALATION;
ISOFLURANE;
HYPOTHERMIA;
D O I：
10.1097/00008506-199103000-00006
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
It is known that hypothermia can improve outcome when induced during ischemia. We evaluated whether hypothermia can decrease ischemic injury if it is induced after incomplete ischemia. Rats were anesthetized with 1.4% inspired isoflurane, and ischemia was produced by right carotid ligation combined with hemorrhagic hypotension to 30 mm Hg for 30 min. Hypothermia (31-degrees-C) was induced or normothermia (37-degrees-C) was maintained for 1 h after completion of the ischemic challenge. Isoflurane anesthesia was maintained during this period. Five of 15 normothermic rats and 3 of 15 hypothermic rats died of stroke after ischemia. For all rats tested, hypothermic-treated animals had a significantly better neurologic outcome than normothermic rats (p < 0.05). Histopathology showed a correlation of r = 0.67 (p < 0.05) with neurologic outcome, and neuronal damage was significantly worse in normothermic compared with hypothermic rats (p < 0.05). These results show that post-ischemic hypothermia will decrease neuronal injury and improve neurologic outcome associated with incomplete ischemia.
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页码：34 / 38
页数：5
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