EFFECT OF WATER ON ENZYMATIC-ACTIVITY AND STEREOSELECTIVITY IN ORGANIC-SOLVENTS - TRANSESTERIFICATION OF A DISUBSTITUTED MALONATE DIESTER

被引：13

作者：

GUTMAN, AL

SHAPIRA, M

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 20期

关键词：

D O I：

10.1039/c39910001467

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction rate and stereoselectivity of the preparatively important enzymatic transesterification of a prochiral symmetrical malonate diester in organic media was shown to be considerably increased by small quantities of added water.

引用

页码：1467 / 1468

页数：2

共 10 条

[1] ENZYME CATALYZED-HYDROLYSIS OF DIALKYLATED PROPANEDIOIC ACID DIESTERS, CHAIN-LENGTH DEPENDENT REVERSAL OF ENANTIOSELECTIVITY [J].

BJORKLING, F ;

BOUTELJE, J ;

GATENBECK, S ;

HULT, K ;

NORIN, T ;

SZMULIK, P .

TETRAHEDRON, 1985, 41 (07) :1347-1352

[2] HOW CAN THE SOLVENT AFFECT ENZYME ENANTIOSELECTIVITY [J].

FITZPATRICK, PA ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (08) :3166-3171

[3] ENZYME-CATALYZED ENANTIOCONVERGENT POLYMERIZATION OF BETA-HYDROXYGLUTARATE IN ORGANIC-SOLVENTS [J].

GUTMAN, AL ;

BRAVDO, T .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (24) :5645-5646

[4] ENZYME-CATALYZED ENANTIOCONVERGENT LACTONIZATION OF GAMMA-HYDROXY DIESTERS IN ORGANIC-SOLVENTS [J].

GUTMAN, AL ;

BRAVDO, T .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (18) :4263-4265

[5] ENZYMATIC RESOLUTION OF RACEMIC AMINES - CRUCIAL ROLE OF THE SOLVENT [J].

KITAGUCHI, H ;

FITZPATRICK, PA ;

HUBER, JE ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (08) :3094-3095

[6] EFFECTS OF WATER AND WATER-MIMICKING SOLVENTS ON THE LIPASE-CATALYZED ESTERIFICATION IN AN APOLAR SOLVENT [J].

KITAGUCHI, H ;

ITOH, I ;

ONO, M .

CHEMISTRY LETTERS, 1990, (07) :1203-1206

[7] ASYMMETRIC TRANSFORMATIONS CATALYZED BY ENZYMES IN ORGANIC-SOLVENTS [J].

KLIBANOV, AM .

ACCOUNTS OF CHEMICAL RESEARCH, 1990, 23 (04) :114-120

[8]

MARGOLIN AL, 1991, CHEMTECH, P160

[9] CONTROL OF ENZYME ENANTIOSELECTIVITY BY THE REACTION MEDIUM [J].

SAKURAI, T ;

MARGOLIN, AL ;

RUSSELL, AJ ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (21) :7236-7237

[10] ENZYME-REACTIONS IN APOLAR SOLVENTS - THE RESOLUTION OF (+-)-SULCATOL WITH PORCINE PANCREATIC LIPASE [J].

STOKES, TM ;

OEHLSCHLAGER, AC .

TETRAHEDRON LETTERS, 1987, 28 (19) :2091-2094

← 1 →