INTERLEUKIN-1 DERIVED SYNTHETIC PEPTIDE AS AN ADDED CO-ADJUVANT IN VACCINE FORMULATIONS

被引：9

作者：

MANIVEL, V ^{[1
]}

RAO, KVS ^{[1
]}

机构：

[1] INT CTR GENET ENGN & BIOTECHNOL, VIROL GRP, NII CAMPUS, SHAHEED JEET SINGH MARG, NEW DELHI 110067, INDIA

来源：

VACCINE | 1991年 / 9卷 / 06期

关键词：

CO-ADJUVANT; INTERLEUKIN-1; SYNTHETIC PEPTIDE; HEPATITIS-B VACCINE;

D O I：

10.1016/0264-410X(91)90124-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A synthetic peptide containing the immunostimulatory and receptor binding sequences of human IL-1-beta was synthesized and tested for its immunoadjuvant properties. Using a commercially available hepatitis B vaccine as model antigen we found that added peptide enhanced both total and protective antibody responses in high and low responder strains of mice but was unable to overcome non-responsivenes in a third strain. Increased antibody response to antigen in the responder strains was not accompanied by any significant alteration in IgG isotype composition. These results suggest that this peptide may prove useful as a co-adjuvant in vaccines.

引用

页码：395 / 397

页数：3

共 10 条

[1]

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[2]

DIGIOVINE FS, 1990, IMMUNOL TODAY, V11, P13

[3]

DINARELLO CA, 1989, ADV IMMUNOL, V44, P153, DOI [10.1016/s0065-2776(08)60642-2, 10.1016/S0065-2776(08)60642-2, DOI 10.1016/S0065-2776(08)60642-2]

[4] HEPATITIS-B SURFACE-ANTIGEN (HBSAG) SUBTYPE-SPECIFIC ANTIBODIES IN PERSONS VACCINATED AGAINST HEPATITIS-B [J].