C-TYPE POTASSIUM CHANNELS IN THE LATERAL CELL-MEMBRANE OF GUINEA-PIG OUTER HAIR-CELLS

被引:26
作者
GITTER, AH
FROMTER, E
ZENNER, HP
机构
[1] UNIV TUBINGEN,HALS NASEN OHREN KLIN,SILCHERSTR 5,W-7400 TUBINGEN 1,GERMANY
[2] UNIV FRANKFURT,ZENTRUM PHYSIOL,W-6000 FRANKFURT 1,GERMANY
关键词
CELL MEMBRANE POTENTIAL DIFFERENCE; COCHLEA; ION CHANNELS; OUTER HAIR CELL; POTASSIUM PERMEABILITY;
D O I
10.1016/0378-5955(92)90053-P
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
The basolateral cell membrane of outer hair cells (OHC) from the mammalian cochlea is known to contain K+-channels. The prevailing type, a high-conductance K+-channel was further characterized in the present study in order to support its classification as C channel. OHC were isolated from the 3rd and 4th turn of the guinea-pig cochlea. Cell-attached and excised inside-out patches of the lateral cell membrane were investigated. The C-type channel had a selectivity for K+ over Na+ of 12:1 to 20:1 and displayed Goldman-type rectification and voltage-dependence of the open probability. The kinetics of both opening and closing could be described by time constants in the range of ms. The channel provides a calcium- and voltage-activated pathway through OHC lateral membranes for passive K+ transport.
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页码:13 / 19
页数:7
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